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KMID : 0359420220400040252
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Korean Journal of Sports Medicine
2022 Volume.40 No. 4 p.252 ~ p.258
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Effects of Prior Short-term Ischemic Preconditioning on Sitting-Induced Lower Limb Vascular Dysfunction in Healthy Men
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Won Jong-Hwa
Jae Sae-Young
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Abstract
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Purpose: The purpose of the study was to examine whether a 7-day ischemic preconditioning (IPC) intervention would attenuate the prolonged sitting-induced lower limb vascular dysfunction in healthy men.
Methods: In a randomized control trial, 12 healthy men (age, 24.9±2.6 years) were assigned to either a 7-day IPC intervention (6×5 minutes of bilateral thigh cuff occlusions at 200 mm Hg) or a sham control group (6×5 minutes of bilateral thigh cuff occlusions at 20 mm Hg). After the 7-day IPC intervention, the participants underwent a 4-hour prolonged sitting. We measured blood pressure, central blood pressure, and superficial femoral artery flow-mediated dilation at baseline (before intervention), pre-sitting (after intervention), post-2-hour sitting, and post-4-hour sitting.
Results: During the 4-hour sitting time, blood pressure and central blood pressure did not significantly change from baseline in any group. However, superficial femoral artery flow-mediated dilation decreased from baseline more so in the sham control group (5.2±1.9 to 1.7±1.2) compared with the IPC group (4.6±2.2 to 3.1±1.5, p=0.015 for interaction).
Conclusion: These findings demonstrate that a 7-day IPC protected against lower limb vascular dysfunction during prolonged sitting in healthy men.
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KEYWORD
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Ischemic preconditioning, Sedentary behavior, Vascular system injuries
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